The podocyte is at the core of kidney function and at the heart of our scientific approach.
The kidney is the organ that is filtering the blood. Blood to be filtered comes via the renal artery (in red), blood filtered leaves in the renal vein (in blue), and the waste products are eliminated in the urine.
Each kidney is divided into individual functional units called nephrons. If the kidney is like a factory, the nephrons are the individual workers, and there are close to one million nephrons per kidney.
The glomerulus is a key element of the nephron where important filtration mechanisms happen. The glomerulus is like the hand of the worker, deciding what is filtered out and what is kept in the blood.
The podocyte is one of the key cell types responsible for the filtration of the blood at a cellular level. The podocytes are like the fingers of a hand, and they wrap around blood vessels like fingers interlocking.
Our unique delivery approach enables us to target the kidney locally, thus reducing vector dose requirements and avoiding systemic distribution.
AAV Vector Capsid & Gene Expression Promoter
Leveraging our capsids and promoters across programs may enable us to shorten development timelines, reduce uncertainty and minimise cost across development and manufacturing.
CMC Processes & Analytics
Our robust CMC processes and proprietary set of CMC analytics are developed in house. These will offer multiple economic, IP and regulatory benefits.