Leading a revolution in the treatment of kidney diseases.
[/vc_column_text][thb_post style=”style9″ animation=”animation top-to-bottom” source=”size:1|post_type:post|categories:3″][vc_empty_space mobile_height=”3vh” height=”3vh”][thb_button_text animation=”animation bottom-to-top” link=”url:%23INTRO|title:DISCOVER|target:_blank”][vc_empty_space mobile_height=”33vh” height=”30vh”][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row thb_full_width=”true” thb_row_padding=”true” thb_column_padding=”true” content_placement=”top” parallax=”content-moving” disable_element=”yes” el_class=”align-center” css=”.vc_custom_1727949266831{border-top-width: 20px !important;border-right-width: 20px !important;border-bottom-width: 20px !important;border-left-width: 20px !important;padding-top: 6vh !important;background-color: #ffffff !important;background-position: center;background-repeat: no-repeat !important;background-size: contain !important;border-left-style: solid !important;border-right-style: solid !important;border-top-style: solid !important;border-bottom-style: solid !important;border-radius: 35px !important;border-color: #ffffff !important;}” el_id=”NEWS”][vc_column offset=”vc_col-lg-10″][vc_row_inner][vc_column_inner][thb_post style=”style9″ animation=”animation top-to-bottom” source=”size:1|post_type:post”][/vc_column_inner][/vc_row_inner][vc_empty_space height=”5vh”][/vc_column][/vc_row][vc_row thb_full_width=”true” thb_row_padding=”true” thb_column_padding=”true” content_placement=”middle” parallax=”content-moving” el_class=”align-center” css=”.vc_custom_1727169880776{margin-bottom: 6vh !important;padding-top: 5vh !important;padding-bottom: 5vh !important;background-color: #ffffff !important;background-position: center;background-repeat: no-repeat !important;background-size: contain !important;}” el_id=”INTRO”][vc_column offset=”vc_col-lg-10″][vc_row_inner][vc_column_inner width=”1/2″ css=”.vc_custom_1516534381846{margin-top: 8vh !important;}”][vc_column_text animation=”animation bottom-to-top”]KIDNEY DISEASES
[/vc_column_text][vc_empty_space height=”5vh”][vc_column_text animation=”animation left-to-right”]Treat kidneys, transform lives.
[/vc_column_text][vc_column_text css=”” animation=”animation bottom-to-top”]At Purespring, we are leading a revolution in the treatment of kidney diseases. The main function of the kidneys is to filter water and waste products out of the blood to create urine. The main filtering units are the glomeruli, which are largely made up of podocytes.The Purespring technology enables delivery of gene therapies specifically to podocytes, creating an opportunity to create novel treatments for a range of genetic and non-genetic glomerular kidney diseases.[/vc_column_text][vc_empty_space height=”40px”][/vc_column_inner][vc_column_inner width=”1/2″ css=”.vc_custom_1626424616620{padding-top: 8vh !important;padding-right: 3vw !important;padding-left: 3vw !important;}”][thb_image retina=”retina_size” animation=”animation top-to-bottom” alignment=”aligncenter” img_size=”full” image=”1014″][/thb_image][vc_empty_space height=”40px”][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row thb_full_width=”true” thb_row_padding=”true” thb_column_padding=”true” full_height=”yes” content_placement=”top” parallax=”content-moving” el_class=”align-center” css=”.vc_custom_1727170781854{border-top-width: 20px !important;border-right-width: 20px !important;border-bottom-width: 20px !important;border-left-width: 20px !important;padding-top: 6vh !important;padding-bottom: 6vh !important;background-color: #f7f7f7 !important;background-position: center;background-repeat: no-repeat;background-size: contain !important;border-left-style: solid !important;border-right-style: solid !important;border-top-style: solid !important;border-bottom-style: solid !important;border-radius: 35px !important;border-color: #ffffff !important;}”][vc_column offset=”vc_col-lg-10″][vc_row_inner][vc_column_inner width=”1/3″][thb_counter style=”counter-style4″ thousand_separator=”” counter=”840″ counter_text=”million” thb_counter_color=”#0f3746″ description=”Suffer from kidney disease globally”][/vc_column_inner][vc_column_inner width=”1/3″][thb_counter style=”counter-style4″ counter=”5-10″ counter_text=”%” description=”Suffer from rare kidney diseases” thb_counter_color=”#0f3746″][/vc_column_inner][vc_column_inner width=”1/3″][thb_counter style=”counter-style4″ counter=”25″ counter_text=”%” description=”Patients on dialysis developed kidney failure due to a rare kidney disease” thb_counter_color=”#0f3746″][/vc_column_inner][/vc_row_inner][vc_empty_space height=”5vh”][vc_row_inner][vc_column_inner width=”1/2″][vc_column_text css=”” animation=”animation bottom-to-top”]Currently over 840 million people globally suffer from chronic kidney disease. Among those 5-10% suffer from rare kidney diseases, the majority of which arise from the glomeruli and involves podocytes. Rare kidney diseases are generally associated with a worse outcome, and approximately 25% of patients on dialysis developed kidney failure due to a rare kidney disease. Purespring exists to change the course of glomerular kidney diseases by providing transformative treatments to make a real difference to patient lives.
Therapeutic innovation has been lacking in renal treatments, and patients are in dire need of new options. At Purespring, we are working toward a future where patients with glomerular kidney disease are empowered with therapies to change the course of their disease.[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/2″][vc_column_text css=”” animation=”animation bottom-to-top”]At present, when patients progress to end-stage renal disease, they are faced with two options, dialysis or kidney transplant, both of which are burdensome, and adversely affect their quality of life with continued risk of complications. Our mission is to bring disease-modifying therapies to these patients. By creating therapies to keep patients with glomerular diseases out of dialysis Purespring will create value for patients, healthcare providers and the broader society.
By bringing the power of gene therapy specifically to podocytes, we aim to stop glomerular kidney diseases in their tracks, and to do so as soon as possible. At Purespring, we are looking to change the status quo, and to do it now with gene therapies designed to target both inherited and common kidney diseases.[/vc_column_text][/vc_column_inner][/vc_row_inner][vc_row_inner][vc_column_inner][vc_empty_space height=”5vh”][thb_button_text animation=”animation bottom-to-top” link=”url:%23PIPELINE|title:MORE|target:_blank”][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row thb_full_width=”true” thb_row_padding=”true” thb_column_padding=”true” full_height=”yes” content_placement=”top” parallax=”content-moving” parallax_image=”62″ el_class=”align-center” css=”.vc_custom_1727170045735{border-top-width: 20px !important;border-right-width: 20px !important;border-bottom-width: 20px !important;border-left-width: 20px !important;padding-top: 6vh !important;padding-bottom: 6vh !important;background-color: #e6f2f3 !important;background-position: center;background-repeat: no-repeat !important;background-size: contain !important;border-left-style: solid !important;border-right-style: solid !important;border-top-style: solid !important;border-bottom-style: solid !important;border-radius: 35px !important;border-color: #ffffff !important;}” el_id=”PIPELINE”][vc_column offset=”vc_col-lg-10″][vc_row_inner css=”.vc_custom_1626422946847{padding-bottom: 5vh !important;}”][vc_column_inner][thb_image retina=”retina_size” animation=”animation bottom-to-top” alignment=”aligncenter” image=”140″ img_size=”100×100″][/thb_image][/vc_column_inner][/vc_row_inner][vc_row_inner][vc_column_inner el_class=”text-center” css=”.vc_custom_1627335887670{padding-right: 3vw !important;padding-left: 3vw !important;}”][vc_column_text css=”” animation=”animation bottom-to-top”]
OUR PIPELINE
[/vc_column_text][vc_column_text animation=”animation bottom-to-top”]Imagine a near future where patients with kidney diseases are empowered with therapies to change the course of their disease.
[/vc_column_text][vc_empty_space height=”5vh”][/vc_column_inner][/vc_row_inner][vc_row_inner thb_max_width=”” content_placement=”top” css=”.vc_custom_1626698310428{padding-right: 5vw !important;padding-left: 5vw !important;}”][vc_column_inner width=”1/2″][vc_column_text css=”” animation=”animation bottom-to-top”]The lead program is PS-002, which controls complement signalling exclusively in the glomeruli, and therefore has the potential to treat a range of glomerular diseases driven by complement activation. PS-002 development will initially focus on IgA nephropathy, and eventually broaden to other complement driven glomerular diseases.[/vc_column_text][/vc_column_inner][vc_column_inner width=”1/2″][vc_column_text css=”” animation=”animation bottom-to-top”]Subsequent Purespring programs will focus on nephropathies driven by monogenic podocyte disorders including NPHS2 nephropathy, glomerular basal membrane deficiencies and a range of other genetic and non-genetic glomerular diseases.[/vc_column_text][/vc_column_inner][/vc_row_inner][vc_row_inner][vc_column_inner el_class=”text-center” css=”.vc_custom_1626442053239{padding-right: 6vw !important;padding-left: 6vw !important;}”][vc_empty_space height=”5vh”][thb_button_text animation=”animation bottom-to-top” link=”url:%23SCIENCE|title:MORE|target:_blank” extra_class=”text-center”][vc_empty_space mobile_height=”10vh” height=””][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row thb_full_width=”true” thb_row_padding=”true” thb_column_padding=”true” full_height=”yes” content_placement=”top” parallax=”content-moving” bg_gradient_direction=”-90″ el_class=”align-center” css=”.vc_custom_1626870988684{border-top-width: 20px !important;border-right-width: 20px !important;border-bottom-width: 20px !important;border-left-width: 20px !important;padding-top: 6vh !important;padding-bottom: 6vh !important;background-color: #82bec3 !important;background-position: center;background-repeat: no-repeat !important;background-size: contain !important;border-left-color: #ffffff !important;border-left-style: solid !important;border-right-color: #ffffff !important;border-right-style: solid !important;border-top-color: #ffffff !important;border-top-style: solid !important;border-bottom-color: #ffffff !important;border-bottom-style: solid !important;border-radius: 35px !important;}” el_id=”SCIENCE” thb_video_bg=”https://purespringtx.com/wp-content/uploads/2021/07/Purespring_SCIENCE_Home.mp4″ bg_gradient1=”rgba(15,55,70,0.6)” bg_gradient2=”rgba(15,55,70,0.4)”][vc_column thb_color=”thb-light-column” el_class=”align-center” offset=”vc_col-lg-11″][vc_row_inner thb_max_width=”” content_placement=”top” css=”.vc_custom_1626702159621{padding-right: 5vw !important;padding-left: 5vw !important;}”][vc_column_inner width=”3/4″][thb_image retina=”retina_size” animation=”animation bottom-to-top” image=”141″ img_size=”100×100″][/thb_image][vc_empty_space height=”3vh”][vc_column_text animation=”animation bottom-to-top”]SCIENCE
[/vc_column_text][vc_empty_space height=”3vh”][vc_column_text css=”” animation=”animation bottom-to-top”]The first gene therapy platform to specifically target kidney diseases.
[/vc_column_text][vc_empty_space height=”5vh”][vc_column_text css=”.vc_custom_1725031752860{padding-right: 6vw !important;}” animation=”animation bottom-to-top”]We understand kidney diseases like nobody else. Based on decades of research from our scientific founder, Professor Moin Saleem, Professor of Paediatric Renal Medicine at the University of Bristol, we now understand that the key to unlocking kidney health is the podocyte, a cell type vital to kidney function. This is why we are developing a proprietary platform and novel treatments focused on targeting the podocyte.[/vc_column_text][vc_empty_space height=”5vh”][thb_button_text animation=”animation bottom-to-top” link=”url:%23LINKS|title:MORE|target:_blank”][vc_empty_space mobile_height=”10vh” height=””][/vc_column_inner][vc_column_inner width=”1/4″][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row thb_full_width=”true” thb_row_padding=”true” thb_column_padding=”true” content_placement=”middle” parallax=”content-moving” disable_element=”yes” el_class=”align-center” css=”.vc_custom_1725031805088{margin-bottom: 6vh !important;padding-top: 5vh !important;padding-right: 5vw !important;padding-bottom: 10vh !important;padding-left: 5vw !important;background-color: #ffffff !important;background-position: center;background-repeat: no-repeat !important;background-size: contain !important;}” el_id=”PEOPLE”][vc_column offset=”vc_col-lg-11″][vc_row_inner][vc_column_inner width=”1/2″ css=”.vc_custom_1626870223710{padding-top: 8vh !important;}”][vc_empty_space height=”5vh”][thb_image retina=”retina_size” animation=”animation fade-in” alignment=”aligncenter” img_size=”full” image=”1222″][/thb_image][/vc_column_inner][vc_column_inner width=”1/2″][thb_image retina=”retina_size” animation=”animation bottom-to-top” image=”138″ img_size=”100×100″][/thb_image][vc_empty_space height=”3vh”][vc_column_text animation=”animation left-to-right”]Your kidney care, in good hands.
[/vc_column_text][vc_empty_space height=”3vh”][vc_column_text animation=”animation left-to-right”]The Purespring team is starting with the future, now.[/vc_column_text][vc_column_text animation=”animation bottom-to-top”]We are a young company drawing on experience from industry and business veterans. We are led by the best people in their fields. Purespring is proudly created and funded by Syncona, a life science investment company with a proven track-record in building innovative gene therapy companies.If you would like to become a Purespringer, join us on our mission to make a difference to patients suffering from kidney diseases.[/vc_column_text][vc_empty_space height=”3vh”][thb_button_text animation=”animation bottom-to-top” link=”url:%23LINKS|title:EXPLORE|target:_blank” extra_class=”text-center”][vc_empty_space height=”40px”][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row][vc_row thb_full_width=”true” thb_row_padding=”true” thb_column_padding=”true” el_id=”LINKS” css=”.vc_custom_1626429326412{margin-bottom: 3vh !important;border-top-width: 25px !important;border-right-width: 25px !important;border-bottom-width: 25px !important;border-left-width: 25px !important;padding-right: 1vw !important;padding-left: 1vw !important;border-left-color: #ffffff !important;border-left-style: solid !important;border-right-color: #ffffff !important;border-right-style: solid !important;border-top-color: #ffffff !important;border-top-style: solid !important;border-bottom-color: #ffffff !important;border-bottom-style: solid !important;border-radius: 35px !important;}”][vc_column][thb_content_carousel thb_columns=”medium-3″ thb_pagination=”” autoplay=”true” thb_margins=”medium-padding”][thb_fancybox height=”50vh” animation=”animation bottom-to-top-3d” thb_text_color=”fancy-light” image=”1046″ bg_gradient1=”#418c9b” bg_gradient2=”#418c9b” border_radius=”15px” link=”url:https%3A%2F%2Fpurespringtx.com%2Fabout%2F|title:About”]